Inhibiting TRAF2-mediated Activation of NF-κB Facilitates Induction of AP-1

The compound 5-(4-methoxyarylimino)-2-N-(3,4-dichlorophenyl)-3-oxo-1,2,4-thiadiazolidine (P(3)-25) is known to possess anti-bacterial, anti-fungal, and anti-tubercular activities. In this report, we provide evidence that P(3)-25 inhibits NF-κB, known to induce inflammatory and tumorigenic responses....

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Detalhes bibliográficos
Main Authors: Manna, Sunil K., Babajan, Banaganapalli, Raghavendra, Pongali B., Raviprakash, Nune, Sureshkumar, Chitta
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2010
Assuntos:
Signal Transduction
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2857039/
https://ncbi.nlm.nih.gov/pubmed/20133937
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.094961
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