Novel Derivative of Benzofuran Induces Cell Death Mostly by G2/M Cell Cycle Arrest through p53-dependent Pathway but Partially by Inhibition of NF-κB

The Dracaena resin is widely used in traditional medicine as an anticancer agent, and benzofuran lignan is the active component. In this report, we provide evidence that the synthetic derivative of benzofuran lignan (Benfur) showed antitumor activities. It induced apoptosis in p53-positive cells. Th...

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Detalhes bibliográficos
Main Authors: Manna, Sunil K., Bose, Julie S., Gangan, Vijay, Raviprakash, Nune, Navaneetha, Thota, Raghavendra, Pongali B., Babajan, Banaganapalli, Kumar, Chitta S., Jain, Swatantra K.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2010
Assuntos:
Signal Transduction
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2903425/
https://ncbi.nlm.nih.gov/pubmed/20472557
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.131797
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