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Unfolding of Metastable Linker Region Is at the Core of Hsp33 Activation as a Redox-regulated Chaperone

Hsp33, a molecular chaperone specifically activated by oxidative stress conditions that lead to protein unfolding, protects cells against oxidative protein aggregation. Stress sensing in Hsp33 occurs via its C-terminal redox switch domain, which consists of a zinc center that responds to the presenc...

תיאור מלא

שמור ב:
מידע ביבליוגרפי
Main Authors: Cremers, Claudia M., Reichmann, Dana, Hausmann, Jens, Ilbert, Marianne, Jakob, Ursula
פורמט: Artigo
שפה:Inglês
יצא לאור: American Society for Biochemistry and Molecular Biology 2010
נושאים:
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC2857002/
https://ncbi.nlm.nih.gov/pubmed/20139072
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.084350
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