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NF-κB Activation in T Cells Requires Discrete Control of IκB Kinase α/β (IKKα/β) Phosphorylation and IKKγ Ubiquitination by the ADAP Adapter Protein

NF-κB activation following engagement of the antigen-specific T cell receptor involves protein kinase C-θ-dependent assembly of the CARMA1-BCL10-MALT1 (CBM) signalosome, which coordinates downstream activation of IκB kinase (IKK). We previously identified a novel role for the adhesion- and degranula...

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主要な著者: Srivastava, Rupa, Burbach, Brandon J., Shimizu, Yoji
フォーマット: Artigo
言語:Inglês
出版事項: American Society for Biochemistry and Molecular Biology 2010
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC2856986/
https://ncbi.nlm.nih.gov/pubmed/20164171
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.068999
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