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Caspase cleavage of the amyloid precursor protein is prevented after overexpression of bcl-2 in a triple transgenic mouse model of Alzheimer's disease

A recent study demonstrated the lack of beta-amyloid (Aβ) plaque formation and accumulation of the amyloid precursor protein (APP) in a triple transgenic mouse model of Alzheimer's disease (3xTg-AD) following overexpression of the anti-apoptotic protein, Bcl-2 (Rohn et al., J. Neurosci. 28: 305...

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Autori principali: Kumasaka, Debra K, Galvan, Veronica, Head, Elizabeth, Rohn, Troy T
Natura: Artigo
Lingua:Inglês
Pubblicazione: e-Century Publishing Corporation 2009
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2856934/
https://ncbi.nlm.nih.gov/pubmed/20411026
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