PINK1 stabilized by mitochondrial depolarization recruits Parkin to damaged mitochondria and activates latent Parkin for mitophagy

Parkinson's disease (PD) is a prevalent neurodegenerative disorder. Recent identification of genes linked to familial forms of PD such as Parkin and PINK1 (PTEN-induced putative kinase 1) has revealed that ubiquitylation and mitochondrial integrity are key factors in disease pathogenesis. Howev...

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Autori principali: Matsuda, Noriyuki, Sato, Shigeto, Shiba, Kahori, Okatsu, Kei, Saisho, Keiko, Gautier, Clement A., Sou, Yu-shin, Saiki, Shinji, Kawajiri, Sumihiro, Sato, Fumiaki, Kimura, Mayumi, Komatsu, Masaaki, Hattori, Nobutaka, Tanaka, Keiji
Natura: Artigo
Lingua:Inglês
Pubblicazione: The Rockefeller University Press 2010
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Research Articles
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2856912/
https://ncbi.nlm.nih.gov/pubmed/20404107
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.200910140
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