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Dicer's helicase domain is required for accumulation of some, but not all, C. elegans endogenous siRNAs
Years after the discovery that Dicer is a key enzyme in gene silencing, the role of its helicase domain remains enigmatic. Here we show that this domain is critical for accumulation of certain endogenous small interfering RNAs (endo-siRNAs) in Caenorhabditis elegans. The domain is required for the p...
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| Autori principali: | , , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Cold Spring Harbor Laboratory Press
2010
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2856884/ https://ncbi.nlm.nih.gov/pubmed/20354150 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1261/rna.2122010 |
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