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Polymerase incorporation and miscoding properties of 5-chlorouracil

Inflammation-mediated hypochlorous acid (HOCl) can damage DNA, DNA precursors, and other biological molecules, thereby producing an array of damage products such as 5-chlorouracil (ClU). In this study, we prepared and studied 5-chloro-2’-deoxyuridine (CldU) and ClU-containing oligonucleotide templat...

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Détails bibliographiques
Auteurs principaux: Kim, Cherine H., Darwanto, Agus, Theruvathu, Jacob A., Herring, Jason L., Sowers, Lawrence C.
Format: Artigo
Langue:Inglês
Publié: 2010
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2856725/
https://ncbi.nlm.nih.gov/pubmed/20104909
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/tx900302j
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