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Base-pairing Configuration and Stability of an Oligonucleotide Duplex Containing a 5-Chlorouracil-Adenine Base Pair

Inflammation-mediated reactive molecules can damage DNA by oxidation and chlorination. The biological consequences of this damage are as yet incompletely understood. In this paper, we have constructed oligonucleotides containing 5-chlorouracil (ClU), one of the known inflammation damage products. Th...

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Detalhes bibliográficos
Main Authors: Theruvathu, Jacob A., Kim, Cherine H., Rogstad, Daniel K., Neidigh, Jonathan W., Sowers, Lawrence C.
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3985277/
https://ncbi.nlm.nih.gov/pubmed/19618901
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi9007947
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