A novel approach to investigate tissue-specific trinucleotide repeat instability

BACKGROUND: In Huntington's disease (HD), an expanded CAG repeat produces characteristic striatal neurodegeneration. Interestingly, the HD CAG repeat, whose length determines age at onset, undergoes tissue-specific somatic instability, predominant in the striatum, suggesting that tissue-specifi...

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Détails bibliographiques
Auteurs principaux: Lee, Jong-Min, Zhang, Jie, Su, Andrew I, Walker, John R, Wiltshire, Tim, Kang, Kihwa, Dragileva, Ella, Gillis, Tammy, Lopez, Edith T, Boily, Marie-Josee, Cyr, Michel, Kohane, Isaac, Gusella, James F, MacDonald, Marcy E, Wheeler, Vanessa C
Format: Artigo
Langue:Inglês
Publié: BioMed Central 2010
Sujets:
Research article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2856555/
https://ncbi.nlm.nih.gov/pubmed/20302627
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1752-0509-4-29
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