Loss of Dact1 Disrupts Planar Cell Polarity Signaling by Altering Dishevelled Activity and Leads to Posterior Malformation in Mice

Wnt signaling plays a key role in embryogenesis and cancer development. Dvl (Dishevelled) is a central mediator for both the canonical and noncanonical Wnt pathways. Dact1 (Dapper1, Dpr1), a Dvl interactor, has been shown to negatively modulate Wnt signaling by promoting lysosomal degradation of Dvl...

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Autors principals: Wen, Jun, Chiang, Y. Jeffrey, Gao, Chan, Xue, Hua, Xu, Jingyue, Ning, Yuanheng, Hodes, Richard J., Gao, Xiang, Chen, Ye-Guang
Format: Artigo
Idioma:Inglês
Publicat: American Society for Biochemistry and Molecular Biology 2010
Matèries:
Developmental Biology
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2856307/
https://ncbi.nlm.nih.gov/pubmed/20145239
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.085381
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