Loss of Dishevelleds disrupts planar polarity in ependymal motile cilia and results in hydrocephalus

Defects in ependymal (E) cells, which line the ventricle and generate cerebrospinal fluid flow through ciliary beating, can cause hydrocephalus. Dishevelled genes (Dvls) are essential for Wnt signaling and Dvl2 has been shown to localize to the rootlet of motile cilia. Using the hGFAP-Cre;Dvl1(−/−);...

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Detalhes bibliográficos
Main Authors: Ohata, Shinya, Nakatani, Jin, Herranz-Pérez, Vicente, Cheng, JrGang, Belinson, Haim, Inubushi, Toshiro, Snider, William D., García-Verdugo, Jose Manuel, Wynshaw-Boris, Anthony, Álvarez-Buylla, Arturo
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4126882/
https://ncbi.nlm.nih.gov/pubmed/25043421
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuron.2014.06.022
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