Loss of Dishevelleds disrupts planar polarity in ependymal motile cilia and results in hydrocephalus

Defects in ependymal (E) cells, which line the ventricle and generate cerebrospinal fluid flow through ciliary beating, can cause hydrocephalus. Dishevelled genes (Dvls) are essential for Wnt signaling and Dvl2 has been shown to localize to the rootlet of motile cilia. Using the hGFAP-Cre;Dvl1(−/−);...

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Bibliografiske detaljer
Main Authors: Ohata, Shinya, Nakatani, Jin, Herranz-Pérez, Vicente, Cheng, JrGang, Belinson, Haim, Inubushi, Toshiro, Snider, William D., García-Verdugo, Jose Manuel, Wynshaw-Boris, Anthony, Álvarez-Buylla, Arturo
Format: Artigo
Sprog:Inglês
Udgivet: 2014
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4126882/
https://ncbi.nlm.nih.gov/pubmed/25043421
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuron.2014.06.022
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