Loss of Dact1 Disrupts Planar Cell Polarity Signaling by Altering Dishevelled Activity and Leads to Posterior Malformation in Mice

Wnt signaling plays a key role in embryogenesis and cancer development. Dvl (Dishevelled) is a central mediator for both the canonical and noncanonical Wnt pathways. Dact1 (Dapper1, Dpr1), a Dvl interactor, has been shown to negatively modulate Wnt signaling by promoting lysosomal degradation of Dvl...

תיאור מלא

שמור ב:
מידע ביבליוגרפי
Main Authors: Wen, Jun, Chiang, Y. Jeffrey, Gao, Chan, Xue, Hua, Xu, Jingyue, Ning, Yuanheng, Hodes, Richard J., Gao, Xiang, Chen, Ye-Guang
פורמט: Artigo
שפה:Inglês
יצא לאור: American Society for Biochemistry and Molecular Biology 2010
נושאים:
Developmental Biology
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC2856307/
https://ncbi.nlm.nih.gov/pubmed/20145239
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.085381
תגים: הוספת תג
אין תגיות, היה/י הראשונ/ה לתייג את הרשומה!

פריטים דומים