Angiogenin-induced tRNA-derived Stress-induced RNAs Promote Stress-induced Stress Granule Assembly

Angiogenin (ANG) is a secreted ribonuclease that cleaves tRNA to initiate a stress-response program in mammalian cells. Here we show that ANG inhibits protein synthesis and promotes arsenite- and pateamine A-induced assembly of stress granules (SGs). These effects are abrogated in cells transfected...

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Main Authors: Emara, Mohamed M., Ivanov, Pavel, Hickman, Tyler, Dawra, Nemisha, Tisdale, Sarah, Kedersha, Nancy, Hu, Guo-Fu, Anderson, Paul
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2010
Assuntos:
Cell Biology
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2856301/
https://ncbi.nlm.nih.gov/pubmed/20129916
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.077560
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