Polycystin-1 Protein Level Determines Activity of the Gα(12)/JNK Apoptosis Pathway

Mutations in PKD1 are the most common cause of autosomal dominant polycystic kidney disease (ADPKD). The protein product of PKD1 (polycystin-1 (PC1)) is a large transmembrane protein with a short intracellular C terminus that interacts with numerous signaling molecules, including Gα(12). Cyst format...

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Autori principali: Yu, Wanfeng, Kong, Tianqing, Beaudry, Sarah, Tran, Mei, Negoro, Hideyuki, Yanamadala, Vijay, Denker, Bradley M.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Biochemistry and Molecular Biology 2010
Soggetti:
Signal Transduction
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2856229/
https://ncbi.nlm.nih.gov/pubmed/20106977
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.070821
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