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Identification of Polycystin-1 and Gα12 Binding Regions Necessary for Regulation of Apoptosis
Most patients with Autosomal Dominant Polycystic Kidney Disease (ADPKD) harbor mutations in PKD1 the gene for Polycystin-1 (PC1), a transmembrane protein with a cytoplasmic C-terminus that interacts with numerous signaling molecules, including Gα12. The functions of PC1 and the mechanisms of cyst de...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2998059/ https://ncbi.nlm.nih.gov/pubmed/20837139 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cellsig.2010.09.005 |
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