Insulin-like Growth Factor-1 (IGF-1)-induced Processing of Amyloid-β Precursor Protein (APP) and APP-like Protein 2 Is Mediated by Different Metalloproteinases

α-Secretase cleavage of the amyloid precursor protein (APP) is of great interest because it prevents the formation of the Alzheimer-linked amyloid-β peptide. APP belongs to a conserved gene family including the two paralogues APP-like protein (APLP) 1 and 2. Insulin-like growth factor-1 (IGF-1) stim...

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Autores principales: Jacobsen, Kristin T., Adlerz, Linda, Multhaup, Gerd, Iverfeldt, Kerstin
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2010
Materias:
Signal Transduction
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2856227/
https://ncbi.nlm.nih.gov/pubmed/20139073
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.038224
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