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Unfolding the A2 Domain of Von Willebrand Factor with the Optical Trap

Von Willebrand factor (VWF) is a multimeric plasma glycoprotein involved in both hemostasis and thrombosis. VWF conformational changes, especially unfolding of the A2 domain, may be required for efficient enzymatic cleavage in vivo. It has been shown that a single A2 domain unfolds at most probable...

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書目詳細資料
Main Authors: Ying, Junyi, Ling, Yingchen, Westfield, Lisa A., Sadler, J. Evan, Shao, Jin-Yu
格式: Artigo
語言:Inglês
出版: The Biophysical Society 2010
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC2856187/
https://ncbi.nlm.nih.gov/pubmed/20409490
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2009.12.4324
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