Population pharmacokinetics of melphalan in patients with multiple myeloma undergoing high dose therapy

AIMS: To i) investigate the pharmacokinetics of total and unbound plasma melphalan using a population approach, ii) identify clinical factors that affect melphalan disposition and iii) evaluate the role of melphalan exposure in melphalan-related toxicity and disease response. METHODS: Population pha...

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Detalhes bibliográficos
Main Authors: Nath, Christa E, Shaw, Peter J, Trotman, Judith, Zeng, Lihua, Duffull, Stephen B, Hegarty, Gareth, McLachlan, Andrew J, Gurney, Howard, Kerridge, Ian, Kwan, Yiu Lam, Presgrave, Peter, Tiley, Campbell, Joshua, Douglas, Earl, John
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Science Inc 2010
Assuntos:
Pharmacokinetics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2856049/
https://ncbi.nlm.nih.gov/pubmed/20573084
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1365-2125.2010.03638.x
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