Population pharmacokinetics of melphalan in patients with multiple myeloma undergoing high dose therapy

AIMS: To i) investigate the pharmacokinetics of total and unbound plasma melphalan using a population approach, ii) identify clinical factors that affect melphalan disposition and iii) evaluate the role of melphalan exposure in melphalan-related toxicity and disease response. METHODS: Population pha...

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Autori principali: Nath, Christa E, Shaw, Peter J, Trotman, Judith, Zeng, Lihua, Duffull, Stephen B, Hegarty, Gareth, McLachlan, Andrew J, Gurney, Howard, Kerridge, Ian, Kwan, Yiu Lam, Presgrave, Peter, Tiley, Campbell, Joshua, Douglas, Earl, John
Natura: Artigo
Lingua:Inglês
Pubblicazione: Blackwell Science Inc 2010
Soggetti:
Pharmacokinetics
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2856049/
https://ncbi.nlm.nih.gov/pubmed/20573084
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1365-2125.2010.03638.x
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