High melphalan exposure is associated with improved overall survival in myeloma patients receiving high dose melphalan and autologous transplantation

AIM: High dose melphalan (HDM) and autologous stem cell transplantation (ASCT) retains a central role in the treatment of myeloma. The aim of this study was to determine whether HDM exposure (area under the concentration vs. time curve, AUC), is significantly associated with transplant outcomes. MET...

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Detalhes bibliográficos
Publicado no:Br J Clin Pharmacol
Main Authors: Nath, Christa E., Trotman, Judith, Tiley, Campbell, Presgrave, Peter, Joshua, Douglas, Kerridge, Ian, Kwan, Yiu Lam, Gurney, Howard, McLachlan, Andrew J., Earl, John W., Nivison‐Smith, Ian, Zeng, Lihua, Shaw, Peter J.
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2016
Assuntos:
Pharmacokinetic Dynamic Relationships
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4917807/
https://ncbi.nlm.nih.gov/pubmed/26879446
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bcp.12906
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