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Lymph node–resident lymphatic endothelial cells mediate peripheral tolerance via Aire-independent direct antigen presentation

Peripheral immune tolerance is generally thought to result from cross-presentation of tissue-derived proteins by quiescent tissue-resident dendritic cells to self-reactive T cells that have escaped thymic negative selection, leading to anergy or deletion. Recently, we and others have implicated the...

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Autors principals: Cohen, Jarish N., Guidi, Cynthia J., Tewalt, Eric F., Qiao, Hui, Rouhani, Sherin J., Ruddell, Alanna, Farr, Andrew G., Tung, Kenneth S., Engelhard, Victor H.
Format: Artigo
Idioma:Inglês
Publicat: The Rockefeller University Press 2010
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2856027/
https://ncbi.nlm.nih.gov/pubmed/20308365
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20092465
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