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Upregulation of Nox4 by hypertrophic stimuli promotes apoptosis and mitochondrial dysfunction in cardiac myocytes

RATIONALE: NADPH oxidases are a major source of superoxide (O(2)(−)) in the cardiovascular system. The function of Nox4, a member of the Nox family of NADPH oxidases, in the heart is poorly understood. OBJECTIVE: The goal of this study was to elucidate the role of Nox4 in mediating oxidative stress...

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Main Authors: Ago, Tetsuro, Kuroda, Junya, Pain, Jayashree, Fu, Cexiong, Li, Hong, Sadoshima, Junichi
Format: Artigo
Jezik:Inglês
Izdano: 2010
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2855780/
https://ncbi.nlm.nih.gov/pubmed/20185797
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCRESAHA.109.213116
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