Evidence of RNAi in humans from systemically administered siRNA via targeted nanoparticles

Therapeutics that are designed to engage RNA interference (RNAi) pathways have the potential to provide new, major ways of imparting therapy to patients.1,2 Fire et al. first demonstrated that long, double stranded RNAs mediate RNAi in Caenorhabditis elegans,3 and Elbashir et al. opened the pathway...

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Bibliografiske detaljer
Main Authors: Davis, Mark E., Zuckerman, Jonathan E., Choi, Chung Hang J., Seligson, David, Tolcher, Anthony, Alabi, Christopher A., Yen, Yun, Heidel, Jeremy D., Ribas, Antoni
Format: Artigo
Sprog:Inglês
Udgivet: 2010
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2855406/
https://ncbi.nlm.nih.gov/pubmed/20305636
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature08956
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