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Correlating animal and human phase Ia/Ib clinical data with CALAA-01, a targeted, polymer-based nanoparticle containing siRNA

Nanoparticle-based experimental therapeutics are currently being investigated in numerous human clinical trials. CALAA-01 is a targeted, polymer-based nanoparticle containing small interfering RNA (siRNA) and, to our knowledge, was the first RNA interference (RNAi)–based, experimental therapeutic to...

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Hlavní autoři: Zuckerman, Jonathan E., Gritli, Ismael, Tolcher, Anthony, Heidel, Jeremy D., Lim, Dean, Morgan, Robert, Chmielowski, Bartosz, Ribas, Antoni, Davis, Mark E., Yen, Yun
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2014
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4128111/
https://ncbi.nlm.nih.gov/pubmed/25049380
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1411393111
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