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Polycation-siRNA nanoparticles can disassemble at the kidney glomerular basement membrane
Despite being engineered to avoid renal clearance, many cationic polymer (polycation)-based siRNA nanoparticles that are used for systemic delivery are rapidly eliminated from the circulation. Here, we show that a component of the renal filtration barrier—the glomerular basement membrane (GBM)—can d...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3286910/ https://ncbi.nlm.nih.gov/pubmed/22315430 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1200718109 |
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