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Cytotoxic T Lymphocyte Responses to Transgene Product, Not Adeno-Associated Viral Capsid Protein, Limit Transgene Expression in Mice

The use of adeno-associated viral (AAV) vectors for gene replacement therapy is currently being explored in several clinical indications. However, reports have suggested that input capsid proteins from AAV-2 vector particles may result in the stimulation of cytotoxic T lymphocyte (CTL) responses tha...

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Detalhes bibliográficos
Main Authors: Siders, William M., Shields, Jacqueline, Kaplan, Johanne, Lukason, Michael, Woodworth, Lisa, Wadsworth, Sam, Scaria, Abraham
Formato: Artigo
Idioma:Inglês
Publicado em: Mary Ann Liebert, Inc. 2009
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2855252/
https://ncbi.nlm.nih.gov/pubmed/18828728
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/hum.2008.055
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