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Novel Role for E4 Region Genes in Protection of Adenovirus Vectors from Lysis by Cytotoxic T Lymphocytes

Target cells infected with adenovirus (Ad) vectors containing intact E3 and E4 regions were found to be relatively resistant to lysis by Ad-specific cytotoxic T lymphocytes. Elements from both the E3 and the E4 regions were required for this effect, leading to the identification of a previously unde...

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Publicado no:J Virol
Principais autores: Kaplan, Johanne M., Armentano, Donna, Scaria, Abraham, Woodworth, Lisa A., Pennington, Sarah E., Wadsworth, Samuel C., Smith, Alan E., Gregory, Richard J.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 1999
Assuntos:
Gene Therapy
Acesso em linha:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC104342/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10196353/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jvi.73.5.4489-4492.1999
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