Generation of cytotoxic T lymphocytes against immunorecessive epitopes after multiple immunizations with adenovirus vectors is dependent on haplotype.

Currently, adenovirus (Ad) is being considered as a vector for the treatment of cystic fibrosis as well as other diseases. However, the cytotoxic T lymphocyte (CTL) response to Ad could limit the effectiveness of such approaches. Since the CTL response to virus infection is often focused on one or a...

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Detalhes bibliográficos

Publicado no:	J Virol
Principais autores:	Sparer, T E, Wynn, S G, Clark, D J, Kaplan, J M, Cardoza, L M, Wadsworth, S C, Smith, A E, Gooding, L R
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Society for Microbiology (ASM) 1997
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC191336/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9032363/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jvi.71.3.2277-2284.1997
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