Generation of cytotoxic T lymphocytes against immunorecessive epitopes after multiple immunizations with adenovirus vectors is dependent on haplotype.

Currently, adenovirus (Ad) is being considered as a vector for the treatment of cystic fibrosis as well as other diseases. However, the cytotoxic T lymphocyte (CTL) response to Ad could limit the effectiveness of such approaches. Since the CTL response to virus infection is often focused on one or a...

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Detalhes bibliográficos
Main Authors: Sparer, T E, Wynn, S G, Clark, D J, Kaplan, J M, Cardoza, L M, Wadsworth, S C, Smith, A E, Gooding, L R
Formato: Artigo
Idioma:Inglês
Publicado em: 1997
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC191336/
https://ncbi.nlm.nih.gov/pubmed/9032363
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