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Methionine 286 in transmembrane domain 3 of the GABA(A) receptor β subunit controls a binding cavity for propofol and other alkylphenol general anesthetics
γ-Aminobutyric acid type A (GABA(A)) receptors are an important target for general anesthetics in the central nervous system. Site-directed mutagenesis techniques have identified amino acid residues that are important for the positive modulation of GABA(A) receptors by general anesthetics. In the pr...
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| Главные авторы: | , , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
2001
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2855216/ https://ncbi.nlm.nih.gov/pubmed/11747900 |
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