Intracellular Ca(2+) Silences L-Type Ca(2+) Channels in Mesenteric Veins: Mechanism of Venous Smooth Muscle Resistance to Calcium Channel Blockers

RATIONALE: Calcium channel blockers (CCBs) exert their antihypertensive effect by reducing cardiac afterload but not preload, suggesting that Ca(2+) influx through L-type Ca(2+) channels (LTCC) mediates arterial but not venous tone. OBJECTIVE: The object of this study was to resolve the mechanism of...

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Detalhes bibliográficos
Main Authors: Thakali, Keshari M., Kharade, Sujay V., Sonkusare, Swapnil K., Rhee, Sung W., Stimers, Joseph R., Rusch, Nancy J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2855128/
https://ncbi.nlm.nih.gov/pubmed/20044515
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCRESAHA.109.206763
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