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Opposing roles of smooth muscle BK channels and ryanodine receptors in the regulation of nerve-evoked constriction of mesenteric resistance arteries

In depolarized smooth muscle cells of pressurized cerebral arteries, ryanodine receptors (RyRs) generate “Ca(2+) sparks” that activate large-conductance, Ca(2+)-, and voltage-sensitive potassium (BK) channels to oppose pressure-induced (myogenic) constriction. Here, we show that BK channels and RyRs...

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Detalhes bibliográficos
Main Authors: Krishnamoorthy, Gayathri, Sonkusare, Swapnil K., Heppner, Thomas J., Nelson, Mark T.
Formato: Artigo
Idioma:Inglês
Publicado em: American Physiological Society 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3962638/
https://ncbi.nlm.nih.gov/pubmed/24508642
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpheart.00866.2013
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