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Chimpanzees use More Varied Receptors and Ligands than Humans for Inhibitory KIR Recognition of the MHC-C1 and MHC-C2 Epitopes
Humans and chimpanzees have orthologous MHC class I, but few orthologous KIR. Most divergent are lineage III KIR, which in humans include the inhibitory KIR2DL1 and 2DL2/3 specific for HLA-C. Six lineage III chimpanzee KIR were identified as candidate inhibitory MHC-C receptors and studied using cyt...
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| Main Authors: | , , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
2009
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2854666/ https://ncbi.nlm.nih.gov/pubmed/19265141 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.0803401 |
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