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Chimpanzees use More Varied Receptors and Ligands than Humans for Inhibitory KIR Recognition of the MHC-C1 and MHC-C2 Epitopes

Humans and chimpanzees have orthologous MHC class I, but few orthologous KIR. Most divergent are lineage III KIR, which in humans include the inhibitory KIR2DL1 and 2DL2/3 specific for HLA-C. Six lineage III chimpanzee KIR were identified as candidate inhibitory MHC-C receptors and studied using cyt...

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Detalhes bibliográficos
Main Authors: Moesta, Achim K., Abi-Rached, Laurent, Norman, Paul J., Parham, Peter
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2854666/
https://ncbi.nlm.nih.gov/pubmed/19265141
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.0803401
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