Mutation at Positively Selected Positions in the Binding site for HLA-C Shows KIR2DL1 is a More Refined but Less Adaptable NK cell Receptor than KIR2DL3()

Through recognition of HLA class I, killer cell immunoglobulin-like receptors (KIR) modulate NK cell functions in human immunity and reproduction. Although a minority of HLA-A and –B allotypes are KIR ligands, HLA-C allotypes dominate this regulation, because they all carry either the C1 epitope rec...

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Main Authors: Hilton, Hugo G., Vago, Luca, Older Aguilar, Ana, Moesta, Achim K., Graef, Thorsten, Abi Rached, Laurent, Norman, Paul J., Guethlein, Lisbeth A., Fleischhauer, Katharina, Parham, Peter
Format: Artigo
Language:Inglês
Published: 2012
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3439511/
https://ncbi.nlm.nih.gov/pubmed/22772445
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1100431
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