Slit2–Robo4 signalling promotes vascular stability by blocking Arf6 activity

Slit–Roundabout (Robo) signalling has a well-understood role in axon guidance1–5. Unlike in the nervous system, however, Slitdependent activation of an endothelial-specific Robo, Robo4, does not initiate a guidance program. Instead, Robo4 maintains the barrier function of the mature vascular network...

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Bibliographische Detailangaben
Hauptverfasser: Jones, Christopher A., Nishiya, Naoyuki, London, Nyall R., Zhu, Weiquan, Sorensen, Lise K., Chan, Aubrey C., Lim, Chinten J., Chen, Haoyu, Zhang, Qisheng, Schultz, Peter G., Hayallah, Alaa M., Thomas, Kirk R., Famulok, Michael, Zhang, Kang, Ginsberg, Mark H., Li, Dean Y.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2009
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2854659/
https://ncbi.nlm.nih.gov/pubmed/19855388
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncb1976
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