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Targeted delivery of interferon-alpha via fusion to anti-CD20 results in potent antitumor activity against B-cell lymphoma

The anti-CD20 antibody rituximab has substantially improved outcomes in patients with B-cell non-Hodgkin lymphomas. However, many patients are not cured by rituximab-based therapies, and overcoming de novo or acquired rituximab resistance remains an important challenge to successful treatment of B-c...

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Detalhes bibliográficos
Main Authors: Xuan, Caiyun, Steward, Kristopher K., Timmerman, John M., Morrison, Sherie L.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2010
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2854431/
https://ncbi.nlm.nih.gov/pubmed/20139095
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2009-10-250555
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