Direct and immune-mediated cytotoxicity of interleukin-21 contributes to antitumor effects in mantle cell lymphoma

Mantle cell lymphoma (MCL) is a distinct subtype of non-Hodgkin lymphoma characterized by overexpression of cyclin D1 in 95% of patients. MCL patients experience frequent relapses resulting in median survival of 3 to 5 years, requiring more efficient therapeutic regimens. Interleukin (IL)-21, a memb...

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Publicado en:Blood
Autores principales: Bhatt, Shruti, Matthews, Julie, Parvin, Salma, Sarosiek, Kristopher A., Zhao, Dekuang, Jiang, Xiaoyu, Isik, Elif, Letai, Anthony, Lossos, Izidore S.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society of Hematology 2015
Materias:
Lymphoid Neoplasia
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4582332/
https://ncbi.nlm.nih.gov/pubmed/26194763
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2015-01-624585
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