Novel IL-21 signaling pathway up-regulates c-Myc and induces apoptosis of diffuse large B-cell lymphomas

Interleukin-21 (IL-21), a member of the IL-2 cytokine family, has diverse regulatory effects on natural killer (NK), T, and B cells. In contrast to other cytokines that are usually immunostimulatory, IL-21 can induce apoptosis of murine B cells at specific activation-differentiation stages. This eff...

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Main Authors: Sarosiek, Kristopher A., Malumbres, Raquel, Nechushtan, Hovav, Gentles, Andrew J., Avisar, Eli, Lossos, Izidore S.
格式: Artigo
語言:Inglês
出版: American Society of Hematology 2010
主題:
Lymphoid Neoplasia
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC2810990/
https://ncbi.nlm.nih.gov/pubmed/19965678
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2009-08-239996
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