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Transcriptional silencing of γ-globin by BCL11A involves long-range interactions and cooperation with SOX6
The developmental switch from human fetal (γ) to adult (β) hemoglobin represents a clinically important example of developmental gene regulation. The transcription factor BCL11A is a central mediator of γ-globin silencing and hemoglobin switching. Here we determine chromatin occupancy of BCL11A at t...
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| Main Authors: | , , , , , , |
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| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
Cold Spring Harbor Laboratory Press
2010
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2854393/ https://ncbi.nlm.nih.gov/pubmed/20395365 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.1897310 |
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