Transcriptional silencing of γ-globin by BCL11A involves long-range interactions and cooperation with SOX6

The developmental switch from human fetal (γ) to adult (β) hemoglobin represents a clinically important example of developmental gene regulation. The transcription factor BCL11A is a central mediator of γ-globin silencing and hemoglobin switching. Here we determine chromatin occupancy of BCL11A at t...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Xu, Jian, Sankaran, Vijay G., Ni, Min, Menne, Tobias F., Puram, Rishi V., Kim, Woojin, Orkin, Stuart H.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Cold Spring Harbor Laboratory Press 2010
Pynciau:
Research Paper
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC2854393/
https://ncbi.nlm.nih.gov/pubmed/20395365
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.1897310
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