Possible involvement of Toll-Like Receptor 4/MD-2 activity of opioid inactive isomers causes spinal proinflammation and related behavioral consequences

Opioid-induced glial activation and its proinflammatory consequences have been associated with both reduced acute opioid analgesia and the enhanced development of tolerance, hyperalgesia and allodynia following chronic opioid administration. Intriguingly, recent evidence demonstrates that these effe...

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Main Authors: Hutchinson, Mark R., Lewis, Susannah S., Coats, Benjamen D., Rezvani, Niloofar, Zhang, Yingning, Wieseler, Julie L., Somogyi, Andrew A., Yin, Hang, Maier, Steven F., Rice, Kenner C., Watkins, Linda R.
Format: Artigo
Language:Inglês
Published: 2010
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2854318/
https://ncbi.nlm.nih.gov/pubmed/20178837
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuroscience.2010.02.011
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