Possible involvement of Toll-Like Receptor 4/MD-2 activity of opioid inactive isomers causes spinal proinflammation and related behavioral consequences

Opioid-induced glial activation and its proinflammatory consequences have been associated with both reduced acute opioid analgesia and the enhanced development of tolerance, hyperalgesia and allodynia following chronic opioid administration. Intriguingly, recent evidence demonstrates that these effe...

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Autori principali: Hutchinson, Mark R., Lewis, Susannah S., Coats, Benjamen D., Rezvani, Niloofar, Zhang, Yingning, Wieseler, Julie L., Somogyi, Andrew A., Yin, Hang, Maier, Steven F., Rice, Kenner C., Watkins, Linda R.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2010
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2854318/
https://ncbi.nlm.nih.gov/pubmed/20178837
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuroscience.2010.02.011
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