Single Molecule Kinetics in the Familial Hypertrophic Cardiomyopathy D166V Mutant Mouse Heart

One of the sarcomeric mutations associated with a malignant phenotype of Familial Hypertrophic Cardiomyopathy (FHC) is the D166V point mutation in the ventricular myosin regulatory light chain (RLC) encoded by the MYL2 gene. In this report we show that the rates of myosin cross-bridge attachment and...

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Main Authors: Muthu, P., Mettikolla, P., Calander, N., Luchowski, R., Gryczynski, I., Gryczynski, Z., Szczesna-Cordary, D., Borejdo, J.
Format: Artigo
Sprog:Inglês
Udgivet: 2009
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2854267/
https://ncbi.nlm.nih.gov/pubmed/19914255
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.yjmcc.2009.11.004
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