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CD133(+) Liver Cancer Stem Cells from Methionine Adenosyl Transferase 1A–Deficient Mice Demonstrate Resistance to Transforming Growth Factor (TGF)-β–Induced Apoptosis
Methionine adenosyltransferase (MAT) is an essential enzyme required for S-adenosylmethionine biosynthesis. Hepatic MAT activity falls during chronic liver injury, and mice lacking Mat1a develop spontaneous hepatocellular carcinoma by 18 months. We have previously demonstrated that CD133(+)CD45(−) o...
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| Hoofdauteurs: | , , , , , , |
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| Formaat: | Artigo |
| Taal: | Inglês |
| Gepubliceerd in: |
2009
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| Onderwerpen: | |
| Online toegang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2853874/ https://ncbi.nlm.nih.gov/pubmed/19115422 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/hep.22743 |
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