CD133(+) Liver Cancer Stem Cells from Methionine Adenosyl Transferase 1A–Deficient Mice Demonstrate Resistance to Transforming Growth Factor (TGF)-β–Induced Apoptosis

Methionine adenosyltransferase (MAT) is an essential enzyme required for S-adenosylmethionine biosynthesis. Hepatic MAT activity falls during chronic liver injury, and mice lacking Mat1a develop spontaneous hepatocellular carcinoma by 18 months. We have previously demonstrated that CD133(+)CD45(−) o...

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Autori principali: Ding, Wei, Mouzaki, Marialena, You, Hanning, Laird, Joshua C., Mato, Jose, Lu, Shelly C., Rountree, C. Bart
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2009
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2853874/
https://ncbi.nlm.nih.gov/pubmed/19115422
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/hep.22743
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