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Expansion of Liver Cancer Stem Cells During Aging in Methionine Adenosyltransferase 1A–Deficient Mice
Methionine adenosyltransferase (MAT) is an essential enzyme that catalyzes the biosynthesis of S-adenosylmethionine. Hepatic MAT activity falls in chronic liver diseases, and mice lacking Mat1a are predisposed to liver injury and develop hepatocellular carcinoma (HCC) spontaneously by 18 months. The...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2408692/ https://ncbi.nlm.nih.gov/pubmed/18167064 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/hep.22141 |
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