Role of the Proteasome in Excitotoxicity-Induced Cleavage of Glutamic Acid Decarboxylase in Cultured Hippocampal Neurons

Glutamic acid decarboxylase is responsible for synthesizing GABA, the major inhibitory neurotransmitter, and exists in two isoforms—GAD65 and GAD67. The enzyme is cleaved under excitotoxic conditions, but the mechanisms involved and the functional consequences are not fully elucidated. We found that...

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Autori principali: Baptista, Márcio S., Melo, Carlos V., Armelão, Mário, Herrmann, Dennis, Pimentel, Diogo O., Leal, Graciano, Caldeira, Margarida V., Bahr, Ben A., Bengtson, Mário, Almeida, Ramiro D., Duarte, Carlos B.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2010
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2853570/
https://ncbi.nlm.nih.gov/pubmed/20405034
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0010139
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