Baicalin combats glutamate excitotoxicity via protecting glutamine synthetase from ROS-induced 20S proteasomal degradation

BACKGROUND: Many neuroprotective approaches targeting neurons in animal models fail to provide benefits for the treatment of ischemic stroke in clinic and glial cells have become the targets in some basic studies. Baicalin has neuroprotective effects but the mechanisms related to glial cells are not...

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發表在:Redox Biol
Main Authors: Song, Xianrui, Gong, Zixuan, Liu, Kaili, Kou, Junping, Liu, Baolin, Liu, Kang
格式: Artigo
語言:Inglês
出版: Elsevier 2020
主題:
Research Paper
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC7260594/
https://ncbi.nlm.nih.gov/pubmed/32473460
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.redox.2020.101559
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