Role of the Proteasome in Excitotoxicity-Induced Cleavage of Glutamic Acid Decarboxylase in Cultured Hippocampal Neurons

Glutamic acid decarboxylase is responsible for synthesizing GABA, the major inhibitory neurotransmitter, and exists in two isoforms—GAD65 and GAD67. The enzyme is cleaved under excitotoxic conditions, but the mechanisms involved and the functional consequences are not fully elucidated. We found that...

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Detalhes bibliográficos
Main Authors: Baptista, Márcio S., Melo, Carlos V., Armelão, Mário, Herrmann, Dennis, Pimentel, Diogo O., Leal, Graciano, Caldeira, Margarida V., Bahr, Ben A., Bengtson, Mário, Almeida, Ramiro D., Duarte, Carlos B.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2010
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2853570/
https://ncbi.nlm.nih.gov/pubmed/20405034
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0010139
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